This document presents a critical review of the study titled “Efficacy of the intertransverse process block: single or multiple injection? A randomized, non-inferiority, blinded, cross-over trial in healthy volunteers”. The study compares the efficacy of single versus multiple injections in achieving sufficient block through a non-inferiority trial design. Here, we will evaluate the sample size calculation, methodology, and statistical validity of the non-inferiority approach, with coding examples in R to demonstrate sample size calculations for similar trials.

Regression Project on Coursera - JHU Course