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Estimation of population pharmacokinetics disposition parameters based on characteristic function
Drug plasma levels functions describing for linear models can be based on the convolution product of input function times characteristic function. Most common characteristic function is the poli-exponential one. Basic disposition parameters (clearance, distribution aparent volumens and halflife) dependens only from characteristic function. In this tutorial estimation of population characteristic function using nlme R package, and posterior confidence limits for disposition parameters using a bootstrap method is explained.
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My Work Experience at ICAMMDA.
Using R data Visualization compacted document to learn, while being supervised weekly basis.