MD

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the progressive expansion of kidney cysts, leading to end-stage renal disease. It represents a significant genetic cause of renal failure. The complexity of cellular responses in ADPKD complicates the development of effective treatments, prompting the need for a deeper understanding of the cellular mechanisms driving the disease. This study employs multimodal single-cell analysis to dissect the cellular landscape of ADPKD, utilizing advanced sequencing technologies to examine both the transcriptomes and epigenomes of cells from ADPKD-affected kidneys. By analyzing cells at a single-cell level, the study identifies critical pathways and cellular states associated with disease progression, offering new insights into the roles of specific cell types and their genetic regulators.