Script for testing of generalised linear mixed-effect modelling (GLMM) used for tumour exome SIGNAL mutational signature statistical comparisons, as described in Chapter 4.2.2.4.

Script for tumour exome SIGNAL mutational signature statistical comparisons using generalised linear mixed-effect modelling (GLMM), as described in Chapter 4.2.2.4. A modified version of this script was used for batch processing of multiple individual sample files (available from the author on reasonable request).

Script used for tumour exome mutational signature analysis (for the somatic variant file only), using SignatureEstimation with the COSMIC v2 and v3 signature sets, as described in Chapter 4.2.2.2. A modified version of this script was used for batch processing of multiple files (available from the author on reasonable request).

Script used for tumour exome variant filtering (for both somatic and tumour-only variant files), as described in Chapter 4.1.2.2. A modified version of this script was used for batch processing of multiple files (available from the author on reasonable request).

Script used for variant random sampling analysis, as described in Chapter 3.2.2.3.

Script used for variant analysis, as described in Chapter 3.2.2.4.

Script used for variant analysis, as described in Chapter 3.2.2.3.

Script used for variant analysis, as described in Chapter 3.2.2.2.

Script used for low-frequency LoF variant filtering and analysis, as described in Chapter 3.3.2.1.

Script used for MGRB comparison of candidate genes, as described in Chapter 3.1.2.3.

Script used for variant analysis, as described in Chapter 3.1.2.1.

Script used for variant analysis, as described in Chapter 3.1.2.2.

Script used for variant analysis, as described in Chapter 3.1.2.1.

Script used for variant analysis, as described in Chapter 3.1.2.1.

Script used for variant analysis, as described in Chapter 3.1.2.1.

R code used for exome sequencing data analysis, as described in the Methods section of the above paper.