Drug plasma levels functions describing for linear models can be based on the convolution product of input function times characteristic function. Most common characteristic function is the poli-exponential one. Basic disposition parameters (clearance, distribution aparent volumens and halflife) dependens only from characteristic function. In this tutorial estimation of population characteristic function using nlme R package, and posterior confidence limits for disposition parameters using a bootstrap method is explained.

Short description of beta control chart to analysis tablet manufacture yield. To ilustrate this application, data published by Zadar and Mihelic (Nature Scientific Data doi 10.1038/s41597-022-01203-x) has been used.

Draft about the implementation of the method A to assess the average bioequivalence using replicated designs.

Calculation of the coefficients and exponents for homogenous linear pharmacokinetic models using the matrix method using the R function eigen().