The present report serves to better understand how therapeutics, both Paxlovid and Molnupiravir, have been used and distributed to treat COVID-19. Data come from 11 health systems (Allina Health, CentraCare, Children’s Hospitals and Clinics of Minnesota, Essentia Health, M Health Fairview, University of Minnesota, HealthPartners, Hennepin Healthcare, Mayo Clinic and Mayo Clinic Health System, and North Memorial Health, and Sanford Health) and includes people who resided in Minnesota at the time of treatment or received health care in Minnesota. We estimate that MNEHRC represents around 90 percent of healthcare in the state of Minnesota.